Risk factors associated with Barrett’s epithelial dysplasia

Table 4 Analysis of variance for the three categories of Barrett’s epithelium: non-dysplasia, low-grade dysplasia, and high-grade dysplasia

	No dysplasia (n = 45)	Low grade (n = 14)	High grade (n = 6)	P value
Sex (male/female)	Dec-33	13/1	6/0	0.177
Age (yr)	65.0 ± 9.8	64.3 ± 12.4	63.8 ± 9.4	0.941
Length of BE (SSBE/LSBE)	Feb-43	14/0	4/2	0.044
H. pylori infection rate	Sep-34	6/7	1/5	0.002
p53 positive rate	4/41	7/7	6/0	< 0.001
Body weight (kg)	61.0 ± 9.7	69.5 ± 9.8	65.5 ± 12.5	0.033
BMI (kg/m2)	23.1 ± 2.8	24.0 ± 3.1	23.3 ± 3.7	0.689
Waist circumference (cm)	86.9 ± 7.9	88.1 ± 9.6	89.3 ± 8.4	0.848
GERD	19/26	9/5	0/6	0.020
Hypertension (BP > 130/85)	29/14	6/7	3/3	0.155
Systolic BP (mmHg)	127 ± 16	120 ± 19	125 ± 6	0.473
Diastolic BP (mmHg)	76 ± 10	69 ± 9	71 ± 6	0.016
Diabetes	14/25	7/6	3/3	0.425
Fasting blood glucose (mg/dL)	118 ± 32	113 ± 19	108 ± 20	0.712
HbA1c (%)	5.6 ± 1.0	5.5 ± 0.7	5.5 ± 0.8	0.971
Dyslipidemia	24/19	5/8	3/3	0.612
TG (mg/dL)	144 ± 58	118 ± 71	183 ± 137	0.190
TC (mg/dL)	202 ± 30	195 ± 36	174 ± 25	0.124
HDL-C (mg/dL)	55 ± 13	55 ± 9	48 ± 7	0.407
LDL-C (mg/dL)	118 ± 26	112 ± 33	97 ± 17	0.201
Fatty liver	17/13	5/7	1/1	0.744
γ-GTP (U/L)	55 ± 48	40 ± 31	101 ± 126	0.097
AST (IU/L)	24 ± 8	26 ± 10	24 ± 10	0.837
ALT (IU/L)	24 ± 15	25 ± 13	21 ± 10	0.803
Hs-CRP (mg/dL)	0.107 ± 0.142	0.104 ± 0.126	0.084 ± 0.029	0.973
Metabolic syndrome	15/14	4/7	2/1	0.604

SSBE: Short segment Barrett esophagus; BMI: Body mass index; LSBE: Long-segment Barrett’s esophagus; GERD: Gastroesophageal reflux disease; BP: Blood pressure; TG: Triglyceride; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; hs-CRP: High sensitivity C-reactive protein; GTP: Guanosinetriphosphate.