Risk factors associated with Barrett’s epithelial dysplasia

Table 2 Univariate analysis of variables associated with Barrett’s epithelial dysplasia

	Normal (n = 45)	Dysplasia (n = 20)	P value	OR	95%CI
Sex (male/female)	Dec-33	19/1	0.073	0.145	0.017-1.202
Age (yr)	65.0 ± 9.8	64.2 ± 11.3	0.730	0.991	0.940-1.044
Length of BE (SSBE/LSBE)	Feb-43	18/2	0.402	2.389	0.312-18.294
H. pylori infection rate	34/9 (2)	7/12 (1)	0.0021	0.154	0.047-0.506
p53 positive rate	4/41	13/7	< 0.0011	19.036	4.800-75.499
Body weight (kg)	61.0 ± 9.7	68.2 ± 10.6	0.019	1.081	1.013-1.154
BMI (kg/m2)	23.1 ± 2.8	23.7 ± 3.2	0.451	1.074	0.891-1.295
Waist circumference (cm)	86.9 ± 7.9	88.4 ± 9.0	0.585	1.022	0.945-1.105
GERD	19/26	9/11	0.835	1.120	0.387-3.235
Hypertension (BP > 130/85)	29/14 (2)	9/10 (1)	0.094	0.395	0.133-1.172
Systolic BP (mmHg)	127 ± 16	121 ± 16	0.264	0.980	0.946-1.015
Diastolic BP (mmHg)	76 ± 10	69 ± 8	0.009	0.907	0.843-0.976
Diabetes	14/25 (6)	10/9 (1)	0.188	2.071	0.701-6.124
Fasting blood glucose (mg/dL)	118 ± 32	111 ± 19	0.447	0.992	0.971-1.013
HbA1c (%)	5.6 ± 1.0	5.5 ± 0.7	0.804	0.919	0.470-1.798
Dyslipidemia	24/19 (2)	11/8 (1)	0.322	0.576	0.193-1.715
TG (mg/dL)	144 ± 58	139 ± 98	0.807	0.999	0.991-1.007
TC (mg/dL)	202 ± 30	189 ± 33	0.141	0.987	0.969-1.005
HDL-C (mg/dL)	55 ± 13	53 ± 9	0.850	0.996	0.950-1.043
LDL-C (mg/dL)	118 ± 26	107 ± 30	0.152	0.985	0.964-1.006
Fatty liver	17/13 (15)	6/8 (6)	0.395	0.574	0.159-2.066
γ-GT (U/L)	55 ± 48	59 ± 77	0.781	1.001	0.992-1.011
AST (IU/L)	24 ± 8	25 ± 10	0.769	1.009	0.948-1.075
ALT (IU/L)	24 ± 15	24 ± 12	0.906	0.998	0.958-1.039
hs-CRP (mg/dL)	0.107 ± 0.142	0.101 ± 0.116	0.890	0.706	0.005-98.830
MS	15/14 (16)	6/8 (6)	0.586	0.700	0.194-2.530

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BP: Blood pressure; GT: Glutamyl transpeptidase; HbA1c: Hemoglobin A1c; HDL-C: High-density lipoprotein cholesterol; hs-CRP: High sensitivity C-reactive protein; LDL-C: Low-density lipoprotein cholesterol; TG: Triglyceride; TC: Total cholesterol; H. pylori: Helicobacter pylori.