DNA methylation in gastric cancer, related to Helicobacter pylori and Epstein-Barr virus

Figure 1 Schematic representation about infectious condition and pathogenicity of Helicobacter pylori. Pathogenicity of Helicobacter pylori (H. pylori) is exerted through injection of CagA into gastric epithelial cells using type IV secretion system. Inflammatory cell infiltration due to H. pylori might be more significant factor in induction of aberrant DNA methylation (left). Injection of CagA leads to proliferation of epithelial cells, but it is still unclear whether it plays an important role in methylation induction in epithelial cells (right).