Combined detection tumor markers for diagnosis and prognosis of gallbladder cancer

Table 4 Correlations between gallbladder cancer markers, tumor size, location, and staging

Group	n	MFI (CEA)	MFI (CA199)	MFI (CA125)	MFI (CA242)
Age (yr)
≥ 50	45	9.5 ± 4.3	239.1 ± 324.6	55.9 ± 86.6	39.9 ± 42.9
< 50	33	9.2 ± 2.7	236.9 ± 319.4	54.6 ± 78.9	39.9 ± 47.3
Sex
Male	30	9.3 ± 6.6	234.6 ± 356.9	54.8 ± 81.7	38.5 ± 47.1
Female	48	9.4 ± 3.8	240.4 ± 298.7	55.7 ± 89.5	40.8 ± 49.9
Tumor position
Neck	37	8.5 ± 3.9	262.2 ± 177.8b	62.1 ± 47.0b	42.5 ± 45.9b
Body	23	5.2 ± 4.2	28.3 ± 20.7	56.9 ± 99.7	19.0 ± 21.6
Bottom	5	3.3 ± 2.6	27.6 ± 2.4b	14.5 ± 6.5b	8.5 ± 2.9b
Cystic duct	13	21.5 ± 25.1	622 ± 196.9	49.0 ± 32.9	81.7 ± 56.7
Staging
II	7	3.2 ± 2.2	66.1 ± 6.3a	17.7 ± 7.7a	8.4 ± 3.3a
IIIA	10	2.0 ± 0.9	89.5 ± 8.2	47.3 ± 38.2	10.2 ± 9.9
IIIB	33	6.9 ± 6.4	205.5 ± 33.9a	59.6 ± 114.1a	22 ± 22.6a
IVA	6	3.5 ± 3.3	383.6 ± 55.5a	58.1 ± 25.5a	55.2 ± 25.3a
IVB	22	19.9 ± 9.1	418.7 ± 316.5a	64.1 ± 50.5a	86.2 ± 56.9a
Tumor size
> 5 cm	20	9.6 ± 2.2	768.1 ± 272.9a	82.9 ± 21.9a	81.8 ± 53.1a
≤ 5 cm	58	9.3 ± 1.2	55.4 ± 68.7a	45.8 ± 10.1a	25.5 ± 32.9a
Pathological type
Highly differentiated	8	3.0 ± 2.0	68.9 ± 5.9a	16.7 ± 7.7a	8.7 ± 3.1a
Moderately differentiated	54	6.9 ± 5.9	142.3 ± 200.4	49.9 ± 9.9	33.8 ± 41.3
Poorly differentiated	11	3.5 ± 2.5	649.1 ± 209.1a	84.0 ± 29.4a	73.4 ± 58.9a
Carcinoid	2	20.9 ± 14.6	766.3 ± 330.5a	121.3 ± 45.2a	62.7 ± 9.4a
Squamous cell carcinoma	2	107.5 ± 69.1	334.4 ± 14.9a	116.0 ± 103.1a	108.5 ± 58.7a
Signet ring cell carcinoma	1	31	1000a	89.3a	69.3a

Results are mean ± SD.

^aP < 0.05,

^bP < 0.01 vs control group. MFI: Mean fluorescence intensity; CA: Cancer antigen; CEA: Carcinoembryonic antigen.