Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma

Table 3 Multivariate analysis of clinicopathologic features

Factor	Category	HR	95%CI	P value1
Tumor size	< 5 cm	1.00
	≥ 5 cm	2.00	0.8-3.9	0.157
Differentiation	Well	1.00
	Moderately	0.74	0.3-2.1	0.578
	Poorly	1.65	0.6-4.3	0.335
T stage	T1 + T2	1.00		0.550
	T3 + T4	1.25	0.6-2.6
N stage	N0	1.00		0.015
	N1	3.15	1.3-7.9
M stage	M0	1.00		0.200
	M1	2.18	0.7-7.2
Satellites	Negative	1.00		0.533
	Positive	0.76	0.3-1.8
Macrovascular invasion	Negative	1.00		0.245
	Positive	2.61	0.5-13.2
Microvascualr invasion	Negative	1.00		0.092
	Positive	2.15	0.9-5.2
Intraneural invasion	Negative	1.00		0.927
	Positive	0.95	0.3-2.9
NGF + TrkA	Negative	1.00		0.010
	Positive	2.87	1.3-6.4

¹Cox proportional hazards regression. NGF: Nerve growth factor; TrkA: Tropomyosin-receptor-kinase.