Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma

Table 1 Correlations between nerve growth factor/tropomyosin-receptor-kinase expression and clinicopathologic parameters

Clinicopathologic parameters		n	NGF		P value1	TrkA		P value1
			low	high		low	high
Age	< 65 yr	62	44	18	0.640	49	13	0.850
	≥ 65 yr	21	16	5		13	4
Gender	Male	44	30	14	0.373	32	12	0.099
	Female	39	30	9		34	5
Tumor size	< 5 cm	37	24	13	0.220	28	9	0.438
	≥ 5 cm	46	36	10		38	8
Differentiation	Well	19	9	10	0.024	20	5	0.228
	Moderately	39	32	7		34	5
	Poorly	25	19	6		12	7
T stage	T1	40	29	11	0.200	33	7	0.428
	T2	20	17	3		16	4
	T3	23	14	9		17	6
	T4	0	0	0		0	0
N stage	N0	57	40	17	0.520	46	11	0.695
	N1	26	20	6		20	6
M stage	M0	79	57	22	0.900	63	16	0.823
	M1	4	3	1		3	1
TNM stage	I	31	22	9	0.948	26	5	0.470
	II	10	9	1		8	2
	III	16	9	7		12	4
	IVa	22	17	5		17	5
	IVb	4	3	1		3	1
Satellites	N	63	45	18	0.754	51	12	0.572
	P	20	15	5		15	5
Macrovascular invasion	N	80	57	23	0.158	63	17	0.236
	P	3	3	0		3	0
Microvascular invasion	N	67	48	19	0.786	52	15	0.357
	P	16	12	4		14	2
Intraneural invasion	N	73	53	20	0.864	62	11	0.003
	P	10	7	3		4	6
HBV	N	73	51	22	0.146	57	16	0.347
	P	10	9	1		9	1
Cirrhosis	N	67	48	19	0.786	53	14	0.847
	P	16	12	4		13	3

¹χ² test. NGF: Nerve growth factor; TrkA: Tropomyosin-receptor-kinase; HBV: Hepatitis B virus; N: Negative; P: Positive.