Predictive and prognostic biomarkers with therapeutic targets in advanced colorectal cancer

Table 2 Summary of key biomarkers investigated in clinical trials of bevacizumab

Key biomarkers evaluated
KRAS mutational status
BRAF mutational status
p53 mutational status
VEGF and VEGFR-2 (KDR) gene expression
VEGF A- to VEGF-D, VEGFR-1, and VEGFR-2 protein expression
CD31 expression
Neuropilin expression
Stromal thrombospondin-2 expression
Microvessel density
Plasma VEGF levels

VEGF: Vascular endothelial growth factor.