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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 14, 2014; 20(14): 3847-3857
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3847
Table 2 Molecular markers for the detection of colorectal cancer
MarkersDetection methodSpecimenSensitivitySpecificityRef.
KRASMutation analysisStoolC55%100%Puig et al[67], 2000
A27%100%
APC geneMutation analysisStoolC61%100%Traverso et al[68], 2002
A50%100%
MSI markersDigital-PCR based methodStoolC37%100%Traverso et al[69], 2002
A0%
Long form DNAQuantitative fluorescence determination by PCRStoolC79%89%Calistri et al[70], 2009
Septin 9 methylated DNAReal time PCR analysisPlasmaC72%90%Grützmann et al[42], 2008