Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance

doi:10.3748/wjg.v20.i14.3719

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2014; 20(14): 3719-3737
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3719

Table 2 Adhesion molecules with potential prognostic value in colorectal cancer progression and hepatic metastases[176,194]

Adhesion molecule family	Adhesion molecule	Expression
Cadherins	E-cadherin	Colon epithelial cells
Cadherins	P-cadherin	Colon epithelial cells
Lectins	sLEx	Colon epithelial cells
	sLEa (CA 19-9)
	Galectin-3
Selectins	E-Selectin	ECs
	L-Selectin	Leukocytes
	P-Selectin	ECs and platelets
Integrins	LFA-1 (α_Lβ₂)	Colon epithelial cells, ECs, fibroblasts, leukocytes and platelets
Integrins	VLA-4 (α₄β₁)
Immunoglobulin superfamily CAMs	ICAMs	ECs, fibroblasts and leukocytes
	PECAM-1	ECs, platelets and leukocytes
	VCAM-1	ECs and epithelial cells
	MadCAM	Colon epithelial cells
	CEA	Colon epithelial cells
Proteoglycan receptors	CD44	Colon cells and ECs

CA 19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; EC: Endothelial cell; ICAM: Intercellular adhesion molecule; LFA-1: Leukocyte function-associated antigen 1; MadCAM: Mucosal addressin cell adhesion molecule; PECAM: Platelet endothelial cell adhesion molecule; sLEx: Sialyl Lewis x antigen; VCAM: Vascular cell adhesion molecule; VLA-4: Very late activation antigen 4.

Citation: Paschos KA, Majeed AW, Bird NC. Natural history of hepatic metastases from colorectal cancer - pathobiological pathways with clinical significance. World J Gastroenterol 2014; 20(14): 3719-3737
URL: https://www.wjgnet.com/1007-9327/full/v20/i14/3719.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i14.3719