Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

Figure 3 Immunohistochemical findings of primary biliary cirrhosis with interface hepatitis. Many CD3+ cells were found within the portal tract and at the interface (A), whereas CD38+ cells heavily infiltrated the interface (B), IgG+ cells were mainly found in the portal tract and also at the interface (C), and IgM+ cell infiltration was predominant at the interface (D). Double staining for IgM (red) and CD38 (green) (E) showed that IgM-CD38 double positive cells, IgM-producing plasma cells, were frequently seen in the periportal area (star) (original magnifications: × 200). IgM+ plasma cells were also found around the intralobular bile duct. Asterisk: Hepatic lobule, BD: Bile duct.