Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population

Table 5 Clinical characteristics of patatin-like phospholipase domain-containing protein 3 and apolipoprotein C3 (independently of patatin-like phospholipase domain-containing protein 3 I148M) wild-type homozygotes and carriers of one or more variant alleles in the study population

Characteristic	PNPLA3			APOC3 (independently of PNPLA3 I148M)
	Noncarriers	Carriers	P value	Noncarriers	Carriers	P value
n	231	568		82	149
Female/male	124/107	292/276	0.560	12/70	109/40	0.000
Age (yr)	46.97 ± 16.42	49.41 ± 15.83	0.052	48.89 ± 16.91	45.92 ± 16.11	0.189
BMI (kg/m2)	22.61 ± 4.08	23.84 ± 3.65	0.000	22.04 ± 4.17	22.92 ± 4.00	0.118
Waist (cm)	75.67 ± 9.00	81.59 ± 9.37	0.000	72.96 ± 7.64	77.16 ± 9.37	0.000
ALT (U/L)	36.03 ± 24.46	40.86 ± 35.40	0.028	34.67 ± 20.30	36.77 ± 26.51	0.501
AST (U/L)	34.07 ± 37.80	32.55 ± 37.21	0.601	32.55 ± 37.21	34.07 ± 37.80	0.662
FPG (U/L)	5.30 ± 1.09	5.71 ± 1.54	0.000	5.26 ± 0.82	5.33 ± 1.21	0.618
TG (mmol/L)	2.34 ± 1.54	2.67 ± 1.51	0.005	2.17 ± 1.09	2.43 ± 1.73	0.216
TC (mmol/L)	4.79 ± 0.90	5.03 ± 0.95	0.001	4.72 ± 0.76	4.83 ± 0.97	0.343
HDL (mmol/L)	2.64 ± 2.54	1.82 ± 1.43	0.000	2.88 ± 2.63	2.50 ± 2.48	0.281
LDL (mmol/L)	3.28 ± 1.98	3.90 ± 3.02	0.001	3.44 ± 1.92	3.19 ± 2.01	0.367
FINS (μU/mL)	5.67 ± 1.13	5.97 ± 1.26	0.001	5.58 ± 1.02	5.72 ± 1.20	0.335
HOMA-IR (U)	1.34 ± 0.38	1.52 ± 0.53	0.000	1.31 ± 0.33	1.35 ± 0.41	0.354

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: γ-glutamyltransferase; FPG: Fasting blood glucose; UA: uric Acid; TC: Total cholesterol; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; FINS: Fasting blood insulin; NAFLD: Nonalcoholic fatty liver disease; TG: Triglyceride; HOMA-IR: Homeostatic model assessment of insulin resistance; PNPLA3: Patatin-like phospholipase domain-containing protein 3; APOC3: Apolipoprotein C3.