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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Apr 7, 2014; 20(13): 3609-3614
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3609
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3609
Table 2 Distribution of genotypes in patients and controls n (%)
| Genotype | Complete responders (n = 80) | Partial responders (n = 32) | P value; OR (95%CI) | Non-responders (n = 14) | P value; OR (95%CI) |
| rs1568885 | |||||
| AA | 57 (71.25) | 14 (43.75) | 1.0 (reference) | 4 (28.57) | 1.0 (reference) |
| AT | 21 (26.25) | 14 (43.75) | 0.035; 2.71 (1.11-6.64) | 7 (50) | 0.032; 4.75 (1.26-17.9) |
| TT | 2 (2.5) | 4 (12.5) | 0.024; 8.14 (1.3549.05) | 3 (21.43) | 0.007; 21.37 (2.73-167.2) |
| rs1813443 | |||||
| GG | 46 (57.5) | 10 (31.25) | 1.0 (reference) | 4 (28.57) | 1.0 (reference) |
| GC | 28 (35) | 14 (43.75) | 0.09; 2.3 (0.9-5.87) | 4 (28.57) | 0.7; 1.64 (0.38-7.1) |
| CC | 6 (7.5) | 8 (25) | 0.005; 6.13 (1.74-21.63) | 6 (42.86) | 0.002; 11.5 (2.5-52.84) |
| rs4411591 | |||||
| GG | 54 (67.5) | 17 (53.12) | 1.0 (reference) | 10 (71.43) | 1.0 (reference) |
| GA | 24 (30) | 12 (37.5) | 0.34; 1.58 (0.66-3.84) | 4 (28.57) | 1; 0.9 (0.26-3.16) |
| AA | 2 (2.5) | 3 (9.37) | 0.11; 4.76 (0.73-30.94) | 0 | 1; 1.04 (0.05-23.23) |
- Citation: Thomas D, Gazouli M, Karantanos T, Rigoglou S, Karamanolis G, Bramis K, Zografos G, Theodoropoulos GE. Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn’s disease. World J Gastroenterol 2014; 20(13): 3609-3614
- URL: https://www.wjgnet.com/1007-9327/full/v20/i13/3609.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i13.3609