Association of rs1568885, rs1813443 and rs4411591 polymorphisms with anti-TNF medication response in Greek patients with Crohn’s disease

Table 1 Demographic, clinical and biological characteristics of the study population n (%)

Characteristics	Complete responders	Partial responders	Primary non-responders	P value
	80 (63.49)	32 (25.39)	14 (11.11)
Age (yr, mean ± SD)	28.42 ± 12.85	26.65 ± 14.21	27.32 ± 13.88	0.807
Gender (%)
Male	62 (77.5)	19 (58.37)	8 (57.14)	0.082
Female	18 (22.5)	13 (40.63)	6 (42.86)
CRP levels (mg/dL, mean ± SD)
Pre-treatment (0 wk)	3.47 ± 0.85	5.62 ± 3.44	4.48 ± 2.15	< 0.0001
Post-treatment (12 wk)	1.07 ± 0.72	3.55 ± 1.49	1.61 ± 1.4	< 0.0001
δCRP levels (%)	75.27 ± 36.23	81.03 ± 32.05	63.91 ± 32.73	0.311
Disease years	8 ± 6.48	7.47 ± 5.11	8.18 ± 4.32	0.987
Infliximab dosing (mg/kg)	5	5	5	1.000
Localization (%)
Colitis	26 (32.5)	4 (12.5)	2 (14.28)	0.295
Ileocolitis	50 (62.5)	27 (84.75)	12 (85.72)
Upper gastroenteric	4 (5)	1 (2.75)	0
Behaviour (%)
Inflammatory	34 (42.5)	10 (31.25)	5 (35.71)	0.016
Stricturing	14 (17.5)	9 (28.13)	2 (14.29)
Penetrating	32 (40)	13 (40.62)	7 (50)