Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

Table 6 Comparison of the degree of hepatitis and mononuclear cell infiltration in autoantibody positive and negative groups in primary biliary cirrhosis and autoimmune hepatitis

PBC	AMA(+) or M2(+)	AMA(-) and M2(-)	P value
Comparison between AMA , M2 positive and negative group in PBC
Scores of interface hepatitis1	2.41 ± 0.64 (2)	2.33 ± 0.50 (2)	0.9120
Scores of CD3+ cells at interface2	2.62 ± 1.13 (2)	2.44 ± 1.24 (3)	0.7552
Scores of CD38+ cells at interface2	2.42 ± 1.39 (2.5)	2.33 ± 1.22 (2)	0.9843
Scores of IgG+ cells at interface2	1.12 ± 0.59 (1)	1.22 ± 1.64 (1)	0.4977
Scores of IgM+ cells at interface2	1.00 ± 0.63 (1)	0.89 ± 0.93 (1)	0.4196
Comparison between ANA positive and negative group in PBC
Scores of interface hepatitis1	2.42 ± 0.65 (2)	2.30 ± 0.48 (2)	0.6241
Scores of CD3+ cells at interface2	2.47 ± 1.16 (2)	2.80 ± 1.23 (2)	0.4548
Scores of CD38+ cells at interface2	2.43 ± 1.16 (2)	2.50 ± 1.18 (3)	0.8113
Scores of IgG+ cells at interface2	1.09 ± 1.08 (1)	1.30 ± 0.67 (1)	0.4193
Scores of IgM+ cells at interface2	0.83 ± 0.65 (1)	1.30 ± 0.82 (1)	0.0742
Comparison between ANA positive and negative group in AIH
Scores of interface hepatitis1	2.70 ± 0.64 (3)	2.33 ± 0.58 (2)	0.3543
Scores of CD3+ cells at interface2	4.21 ± 1.13 (4)	3.33 ± 1.53 (3)	0.2965
Scores of CD38+ cells at interface2	3.89 ± 1.18 (4)	2.33 ± 1.15 (3)	0.0692
Scores of IgG+ cells at interface2	1.95 ± 1.39 (2)	1.00 ± 1.00 (1)	0.2552
Scores of IgM+ cells at interface2	0.63 ± 0.76 (1)	0.00 ± 0.00 (0)	0.1141

¹The scores were graded from 2 to 4 for each case, and are shown as the mean ± SD and (median);

²The scores were graded from 0 to 6 for each case, and are shown as the mean ± SD and (median). Anti-mitochondrial antibodies (AMA)(+) ≥ 40; M2(+) ≥ 5; antinuclear antibodies (ANA)(+) ≥ 40. PBC: Primary biliary cirrhosis; AIH: Autoimmune hepatitis.