Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis

Table 3 Degree of mononuclear cell infiltration with respect to immunological phenotypes at the interface and in the hepatic lobules

	PBC1	AIH	P value
At the interface; scores of infiltrating mononuclear cells positive for
CD3	2.8 ± 1.2 (3)2	4.1 ± 1.1 (4)	0.0002
CD4	1.5 ± 1.0 (1)	2.0 ± 1.2 (2)	0.0387
CD8	1.5 ± 0.9 (1)	2.7 ± 1.7 (3)	0.0048
CD20	0.7 ± 0.6 (1)	1.0 ± 1.0 (1)	0.0046
CD38	2.7 ± 1.5 (3)	3.7 ± 1.3 (4)	0.0046
IgG	1.3 ± 1.0 (1)	1.8 ± 1.3 (2)	0.0301
IgM	1.0 ± 0.8 (1)	0.6 ± 0.8 (0.5)	0.0249
IgA	0.5 ± 0.6 (0)	0.6 ± 0.7 (1)	0.4486
In the hepatic lobules; scores of infiltrating mononuclear cells positive for
CD3	2.2 ± 0.9 (2)	3.3 ± 1.3 (3)	0.0016
CD4	0.8 ± 0.9 (0.5)	1.8 ± 1.1 (2)	0.0002
CD8	0.8 ± 0.8 (1)	2.5 ± 1.5 (2)	< 0.0001
CD20	0.3 ± 0.6 (0)	0.7 ± 0.8 (0.5)	0.0147
CD38	1.1 ± 1.0 (1)	2.0 ± 1.2 (2)	0.0025
IgG	0.6 ± 0.8 (0)	1.4 ± 1.3 (1)	0.0007
IgM	0.4 ± 0.5 (0)	0.6 ± 0.7 (0.5)	0.166
IgA	0.3 ± 0.7 (0)	0.6 ± 0.7 (0.5)	0.0239

¹With interface hepatitis;

²The scores were graded from 0-6 for each case, and are shown as the mean ± SD and (median). PBC: Primary biliary cirrhosis; AIH: Autoimmune hepatitis.