Regulatory effect and mechanisms of carbon monoxide-releasing molecule II on hepatic energy metabolism in septic mice

Figure 7 Effect of carbon monoxide-releasing molecule II on hepatic glucokinase activity level in septic mice. Mice were challenged with cecal ligation and puncture (CLP) and treated with tricarbonyldichlororuthenium (II) dimer (CORM-2) or iCORM-2 as described in the Methods section. Hepatic glucokinase activities were assayed by enzyme-linked immunosorbent assay. Compared with the sham group, the CLP group of mice showed a significant increase in hepatic glucokinase (GK) activity. In contrast, the CLP + CORM-2 group showed significantly reduced hepatic GK activity. Results are mean ± SD, ^bP < 0.01 vs sham mice; ^aP < 0.05 vs CLP mice.