Regulatory effect and mechanisms of carbon monoxide-releasing molecule II on hepatic energy metabolism in septic mice

Figure 5 Effect of carbon monoxide-releasing molecule II on plasma aspartate aminotransferase and alanine aminotransferase activities in septic mice. Mice were challenged with cecal ligation and puncture (CLP) and treated with tricarbonyldichlororuthenium (II) dimer (CORM-2) or iCORM-2 as described in the Methods section. Plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities at 24 h after surgery were determined. Plasma activities of ALT (A) and AST (B) were higher in CLP-challenged mice compared with sham mice, whereas ALT and AST activities were markedly decreased after administration of CORM-2. Results are mean ± SD, ^bP < 0.01 vs sham mice; ^aP < 0.05 vs CLP mice.