Regulatory effect and mechanisms of carbon monoxide-releasing molecule II on hepatic energy metabolism in septic mice

Figure 2 Effect of carbon monoxide-releasing molecule II on blood glucose in septic mice. Mice were challenged with cecal ligation and puncture (CLP) and treated with tricarbonyldichlororuthenium (II) dimer (CORM-2) or iCORM-2 as described in the Methods section. Serum glucose concentrations were assessed in all groups of mice preoperatively, and at 1, 2, 4, 6, 8, 10, 12, 16, 20, 24 and 36 h postoperatively. Blood glucose levels in the CLP group decreased to 30%-50% of the normal controls, and remained at these low levels for more than 36 h postoperatively. However, no changes were found in blood glucose levels in the CLP mice after intervention with CORM-2. Results are mean ± SD, ^aP < 0.05 vs sham mice.