Regulatory effect and mechanisms of carbon monoxide-releasing molecule II on hepatic energy metabolism in septic mice

Figure 1 Effect of carbon monoxide-releasing molecule II on survival of septic mice. Mice were challenged with cecal ligation and puncture (CLP) and treated with tricarbonyldi- chlororuthenium (II) dimer (CORM-2) or iCORM-2 as described in the Methods section. All mice had access to water and food. Mouse survival was monitored six times daily for up to 72 h after surgery. Data are shown as the percentage of surviving animals. The survival rate of mice in the CLP group was substantially low, and was only 42% at 24 h and 26% at 48 h postoperatively. In contrast, the survival rate of mice in the CORM-2 group was significantly increased after the CORM-2 intervention, and was 73% at 24 h and 66% at 48 h postoperatively (P < 0.05). Moreover, at 72 h postoperatively, 66% of the mice were still alive.