DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker

Figure 4 Representative dynamic contrast-enhanced magnetic resonance imaging K^trans color maps before treatment (day 0, left hand side) and day 14^th after treatment (right hand side) in two advanced hepatocellular carcinoma patients. Corresponding hypervascular area was indicated by red color. region of interests analysis is more sensitive based on hypervascular part than entire tumor, with mean values. K^trans is a good diagnostic biomarker in differentiation between stable disease (SD, upper row) and progressive disease (PD, lower row) in two patients with hepatocellular carcinoma. Difference of K^trans (∆K^trans ) between SD and PD measured on hypervascular part and entire tumor are both significant. (From reference [58], reprint with permission).