DCE-MRI in hepatocellular carcinoma-clinical and therapeutic image biomarker

Figure 3 Representative dynamic contrast-enhanced magnetic resonance imaging findings in one advanced hepatocellular carcinoma patient. A: Post-contrast T1-weighted magnetic resonance imaging at baseline; B: After 14 d of study treatment; C: Corresponding color K^trans maps at baseline; D: After 14 d of study treatment. Hypervascular area was indicated by red color. The selected region of interest for K^trans measurement was indicated by white arrows. In this patient, the K^trans values at baseline and after study treatment were 798.6 × 10^-3/min and 206.6 × 10^-3/min, respectively; E: The initial area under the gadolinium concentration-time curves (IAUC) at baseline; F: After study treatment from the same patient. The IAUC values at baseline and after study treatment were 1526.2 mmol/kg × s and 1376.1 mmol/kg × s, respectively. (From reference [58], reprint with permission).