Propensity score analysis demonstrated the prognostic advantage of anatomical liver resection in hepatocellular carcinoma

Table 2 Univariate and multivariate analysis of prognostic factors in the one-to-one propensity score-matched pairs

Overall survival	Univariate analysis			Multivariate analysis
Prognostic factors	HR	95%CI	P value	HR	95%CI	P value
Anatomical resection	0.456	0.211-0.983	0.039	0.546	0.205-1.453	0.226
Female gender	0.673	0.157-2.877	0.572
Age	0.994	0.955-1.033	0.747
Background (N + CH)	0.867	0.412-1.825	0.707
Histology (W + M)	0.442	0.194-1.005	0.068
Albumin	0.536	0.187-1.534	0.249
Bilirubin	1.247	0.375-4.145	0.721
Prothrombin time	0.984	0.951-1.019	0.371
ICGR15	1.101	1.047-1.158	< 0.001	1.059	0.990-1.134	0.097
Tumor size	1.151	1.069-1.241	0.001	1.165	0.977-1.389	0.089
No. of tumors	1.075	0.728-1.588	0.723
Absence of VI	0.232	0.109-0.496	< 0.001	0.228	0.092-0.568	0.002
Operative Time	1.003	0.999-1.006	0.189
Blood loss	1.002	1.001-1.002	0.001	1.001	1.000-1.002	0.179
Blood transfusion	1.117	0.914-1.364	0.316
Body mass index	0.957	0.839-1.091	0.509
Platelets	1.023	1.000-1.047	0.109
AST	1.024	1.012-1.037	0.001	1.010	0.994-1.026	0.209
ALT	1.005	0.992-1.019	0.472
MELD	1.067	0.966-1.179	0.278
BTR	0.772	0.557-1.068	0.084
Hyaluronate	1.001	0.999-1.003	0.234
HGF	43.179	2.321-803.29	0.015	52.366	1.310-2094.1	0.035
Alpha-fetoprotein	1	1.000-1.000	0.138
PIVKA	1	1.000-1.000	0.534

P < 0.05 was considered to be significant. N: Normal; CH: Chronic hepatitis; W: Well differentiated hepatocellular carcinoma; M: Moderately differentiated hepatocellular carcinoma; ICGR15: Indocyanine green retention rate at 15 min; VI: Vascular invasion; CI: Confidence interval; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; MELD: Model for end-stage liver disease; BTR: Branched chain amino acids to tyrosine ratio; HGF: Hepatocyte growth factor; PIVKA: Protein induced by vitamin K absence or antagonist.