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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 28, 2014; 20(12): 3112-3124
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3112
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3112
Table 3 Proteomic studies of hepatocellular carcinoma for prediction of recurrence
Ref. | Sample type | Screening platform | Characteristics for distinguishing groups | Candidate biomarkers | Validation method |
Yokoo et al[55] (2007) | Tumour tissues | 2D-DIGE, MALDI-TOF MS | Early IHR within 6 mo after resection | 23 protein panel | 2D-DIGE |
Orimo et al[59] (2008) | Tumour and non-tumour tissues | 2D-DIGE, LC-MS/MS | Histological differentiation of tumours | Adenomatous polyposis coli-end-binding protein 1 (EB1) | IHC |
Yi et al[56] (2008) | Paired tumour and non-tumour tissues | 2DE, MALDI-TOF/TOF MS | Early IHR within 1 yr after resection | Mortalin (HSPA9) | qPCR, Immunoblotting, IHC |
Bai et al[58] (2009) | Tumour tissues | cICAT, 2DLC-MS/MS | Recurrence after liver transplantation | Calpain small subunit 1 (CAPN4) | qRT-PCR, Immunoblotting, TMA |
Cheng et al[57] (2011) | Tumour tissues | 2DE, MALDI-TOF/TOF MS | Recurrence after liver transplantation | N-myc downstream-regulated gene 1 (NDRG1) | Immunoblotting, IHC |
Kanamori et al[60] (2011) | Tumour and non-tumour tissues | 2DLC-MS/MS | Tumour and non-tumour | Talin-1 (TLN1) | IHC |
- Citation: Lee SC, Tan HT, Chung MCM. Prognostic biomarkers for prediction of recurrence of hepatocellular carcinoma: Current status and future prospects. World J Gastroenterol 2014; 20(12): 3112-3124
- URL: https://www.wjgnet.com/1007-9327/full/v20/i12/3112.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i12.3112