Reappraisal of xenobiotic-induced, oxidative stress-mediated cellular injury in chronic pancreatitis: A systematic review

Table 1 Evidence for cytochrome induction in pancreatic acinar cells in chronic pancreatitis

Ref.	Cytochrome	Method of assessment	Histologic verification	Increased expression in acinar cell	Functional correlate
Foster et al[20]	CYP 3A1	Immunohistochemical staining > 50% of healthy donor	No	CYP 3A1	No
	CYP 2E			CYP1A2
	CYP1A2			NADPH 4501
	NADPH 4501
	Glutathione
Wacke et al[21]	CYP1A1	No of cases having high ratios compared to control	Yes	CYP1A12	Yes (verapamil biotransformation)
	CYP1A2			CYP1A2
	CYP2C9			CYP2E1
	CYP2E1			CYP 3A12
	CYP3A1
Standop et al[22]	CYP1A1, 2	Differences in frequency of immunopositivity between normal, CP and cancer	Yes	CYP1A	No
	2B6			CYP 2B6
	2C 8/9/19			CYP 2C8/9/19
	2D6			2D6
	2.00E + 01			NA-OR
	3A4
	NA-OR

¹NADPH cytochrome P 450 reductase;

²Expression similarly increased in normal non-diseased controls. CYP: Cytochrome P450; NA-OR: NADPH oxio reductase.