A randomized trial of iron depletion in patients with nonalcoholic fatty liver disease and hyperferritinemia

Table 2 Independent predictors of improvement of liver damage evaluated by multivariate logistic regression analysis at the end of the trial in 35 patients with nonalcoholic fatty liver disease and hyperferritinemia/increased iron stores (P < 0.0001 for model)

Independent predictors1	OR	95%CI	P value
Iron depletion by phlebotomy	265	8.9-1 × 106	0.0001
AST/ALT ratio	0.86	0.72-0.94	< 0.0001
HOMA-IR index	0.28	0.05-0.65	0.0003

¹Liver damage included direct or indirect evaluation of liver damage in all patients that completed follow-up. AST/ALT: Alanine aminotransferases/aspartate aminotransferases; HOMA-IR: Homeostasis model assessment insulin resistance index.