Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases

Table 2 Summary of selected members of the DEAD-box family that are involved in hepatitis C virus replication and/or have been implicated in the development of hepatocellular carcinoma

Dead-box family	Alternate names	Interaction with HCV	Effect on HCV replication	Ref.	Effect on HCC	Ref.
DDX1	DBP-RB UKVH5d	HCV 3’ (+) UTR and 5’ (-) UTR	Unknown	NA	Unknown	NA
DDX3	DDX3X DBX DDX14 HLP2	HCV core	Required for HCV replication	Ariumi et al[59] Randall et al[60] Angus et al[66]	Overexpressed in HCC	Huang et al[97] Li et al[98] Liu et al[99]
					Downregulated in HCC	Chang et al[100] Chao et al[101]
DDX5	p68 G17P1 HLR1 HUMP68	HCV NS5B	Inhibit an early step and promote a late step in viral replication	Data presented herein Kuroki et al[75]	Downregulated in HCC	Kitagawa et al[86]
DDX6	Rck P54 HLR2	HCV core	Required for HCV replication	Scheller et al[78] Jangra et al[79] Pager et al[80] Huys et al[81]	Overexpressed in HCC	Miyaji et al[88]
DDX17	P72 RP3-434P1.1 RH70	Unknown	Unknown	NA	Downregulated in HCC	Kitagawa et al[86]
DDX20	Gemin3 DP103	Unknown	Unknown	NA	Downregulated in HCC	Takata et al[94]

HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; NA: Not applicable.