Non-invasive diagnosis of liver fibrosis in chronic hepatitis C

Table 2 Selected models including indirect markers of liver fibrosis

Score (original reference)	Variables	Performance in HCV patients1
		Significant fibrosis (≥F2)			Cirrhosis (≥F4)
		Median AUROC	Median sensitivity2	Median specificity2	Median AUROC	Median sensitivity2	Median specificity2
APRI[24]	AST and platelet count	0.77	81%	95%	0.84	77%	94%
FIB-43[41]	Age, AST, ALT and platelet count	0.74	64%	79%	0.87	90%	92%
Forns index[48]	Age, platelet count, cholesterol levels, and GGT	0.76	88%	94%	0.87	98%	91%
Fibro index[50]	Platelet count, AST, and gamma globulin	0.76	94%	97%	0.86	70%	91%

¹Based on reference number 49;

²Sensitivity values are presented for the lower cutoff and specificity for the upper cutoff (when multiple cutoffs are presented); ³Model originally proposed for HIV/HCV co-infected patients. HCV: Hepatitis C virus; AUROC: Area under the receiver operating characteristic curve; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyltransferase; HIV: Human immunodeficiency virus.