Role of macrophages and monocytes in hepatitis C virus infections

Table 1 Transmission of hepatitis C virus into various hematopoetic and liver cells

	Short term replication	Long term replication
T-cells1	+	-
B-cells2	+	+
Monocytes/ macrophages3	+	-
Neuronal precursors4	+	+
Liver cells5
Kupffer cells	+	-
Hepatocyte	+	+/-

Adapted from reference[55].

¹T-cells isolated from human fetal cord blood;

²B-cells immortalized by infection with transforming Epstein-Barr virus;

³Monocyte/macrophages: adherent cells stimulated with phorbol-12-myristate-13-acetate;

⁴Recently isolated neuronal cells from fetal human brain;

⁵Freshly isolated liver cells from liver biopsies. Kupffer cells are liver macrophages and hepatocytes are liver endothelial cells.