ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn’s disease patients

Figure 4 Phagocytosis and variants in Crohn’s disease associated genes autophagy related like 1, immunity-related guanosine triphosphatase gene and nucleotide-binding ligomerization domain-containing protein 2. A, B: Genotypes in immunity-related guanosine triphosphatase variant and association with either phagocytic activity or the percentage of active monocytes, respectively; C, D: Genotypes of the autophagy related like 1 variant associated with enhanced phagocytic activity (P = 0.009) and percentage of active monocytes respectively. ^bP < 0.01 vs genetype 3; E, F: The genotype of the variant 3020 C-ins of nucleotide-binding ligomerization domain-containing protein 2 and phagocytic activity as well as the percentage of active monocytes (P = 0.05) respectively. Genotypes 1: Wild type; Genotypes 2: Heterozygous variant; Genotypes 3: Homozygous variant.