Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats

Figure 6 Effects of exenatide on the expression levels of mitochondrial morphologic regulators in adipose tissue. Genes involved in mitochondrial fusion [mitofusin-1 (Mfn1) and mitofusin-2 (Mfn2) and optic atrophy-1 (Opa1)] were significantly greater in the high-fat diet (HFD)-Ex(+) group than in the control and HFD-Ex(-) groups. The expression of dynamin-1 (Dnm1), which is involved in mitochondrial fission, was not significantly different between the HFD-Ex(+) and HFD-Ex(-) groups. The fold changes were calculated as the ratio of the expression level in the HFD-Ex(+) or HFD-Ex(-) group to that in the control group. n = 8, ^aP < 0.05 between groups.