Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats

Figure 5 Effects of exenatide on the expression levels of genes associated with lipid metabolism, reactive oxygen species elimination, and macrophage activation in adipose tissue. A: The expression levels of hormone-sensitive lipase (HSL), carnitine palmitoyltransferase-1 (CPT1), long-chain acyl-CoA dehydrogenase (LCAD), and acyl-CoA oxidase 1 (ACOX1) were significantly greater in the high-fat diet (HFD)-Ex(+) group than in the control and HFD-Ex(-) groups; B: The expression levels of catalase and superoxide dismutase (SOD)2 were significantly greater in the HFD-Ex(+) group than in the control and HFD-Ex(-) groups. There were no significant differences in tumor necrosis factor (TNF) or monocyte chemotactic protein 1 (MCP1) expression levels among the three groups. The fold changes were calculated as the ratio of the expression level in the HFD-Ex(+) or HFD-Ex(-) group to that in the control group. n = 8, ^aP < 0.05 between groups.