Exenatide improves hepatic steatosis by enhancing lipid use in adipose tissue in nondiabetic rats

Figure 3 Histological evaluation of lipid accumulation in the liver and adipose tissue. A: Numerous hepatocytes containing lipid droplets were observed in the high-fat diet (HFD)-Ex(-) group, whereas scant lipid-containing hepatocytes were found in the HFD-Ex(+) group; B: In epididymal white adipose tissue, there were abundant enlarged adipocytes in the HFD-Ex(-) group but not in the HFD-Ex(+) group; C: The number of hepatic lipid droplets was significantly decreased in the HFD-Ex(+) group compared with the HFD-Ex(-) group; D: The mean diameter of adipocytes in the HFD-Ex(+) group was significantly smaller than that in the HFD-Ex(-) group and was similar to that in the control group. The fold changes were calculated as the ratio of the average size of adipocytes in the HFD-Ex(+) or HFD-Ex(-) group to that in the control group. n = 5, ^aP < 0.05 between groups. Scale bar = 100 μm. ND: Not detected.