Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats

Figure 7 Effects of low molecular sodium alginate on indomethacin-induced small intestinal lesions. Animals were given indomethacin (10 mg/kg, po) and killed 24 h later. Original AL-Na (500 mg/kg), low AL-Na (500 mg/kg) or CMC-Na (250 mg/kg) was given orally twice at 30 min before and 6 h after administration of indomethacin. (A) The lesion areas were measured. (B) The vascular permeability was measured. Each column and vertical bar represents the mean ± SE (n = 8). Significantly different from the control group at ^bP < 0.01 (Student’s t-test). Significantly different from the indomethacin group at ^aP < 0.05 and ^dP < 0.01 (Dunnett’s test). Cont: Control; IND: Indomethacin; AL-Na: Sodium alginate; Low AL-Na: Low molecular sodium alginate; CMC-Na: Sodium carboxymethylcellulose.