Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats

Figure 4 Effects of drugs on indomethacin-induced atrophy. Animals were given indomethacin (10 mg/kg, po) and killed 24 h later. AL-Na (250 and 500 mg/kg) or Reb (100 mg/kg) was given orally twice at 30 min before and 6 h after administration of indomethacin. A: The small intestinal length was measured; B: Microscopic observations with proliferating cell nuclear antigen (PCNA) positive cells of the rat ileal mucosa of the control (Cont) group; C: Indomethacin (IND); D: AL-Na (250 mg/kg); E: AL-Na (500 mg/kg); F: Reb (100 mg/kg). Each column and vertical bar represents the mean ± SE (n = 8). Significantly different from the Cont group at ^aP < 0.05 (Student’s t-test); Significantly different from the IND group at ^cP < 0.05 (Dunnett’s test). AL-Na: Sodium alginate; Reb: Rebamipide. The allows show PCNA positive cells.