Sodium alginate ameliorates indomethacin-induced gastrointestinal mucosal injury via inhibiting translocation in rats

Figure 1 Effects of drugs on indomethacin-induced gastric lesions. Animals were given indomethacin (25 mg/kg, po) and killed 6 h later. AL-Na (250 and 500 mg/kg) or Reb (100 mg/kg) was given orally at 30 min before administration of indomethacin. The lesion areas (A) and myeloperoxidase (MPO) activity were measured (B). C: Hematoxylin and eosin stained microscopic observations of the rat gastric mucosa of the control (Cont) group; D: Indomethacin (IND); E: AL-Na (250 mg/kg); F: AL-Na (500 mg/kg); G: Reb (100 mg/kg). Each column and vertical bar represents the mean ± SE (n = 8). Significantly different from the Cont group at ^bP < 0.01 (Student’s t-test). Significantly different from the IND group at ^aP < 0.05 and ^dP < 0.01, respectively (Dunnett’s test). AL-Na: Sodium alginate; Reb: Rebamipide.