Evaluation of renal function in patients with cirrhosis: Where are we now?

Table 2 Description of the characteristics of the studies used to develop the common glomerular filtration rate estimates

Name of the study	Number of patients	Country	Reference method	Marker(s)	Mean GFR	Comments
CG 1976	249	Canada	24 h ClCr	SCr	30-130	No normalization on BSA
						Male patients only in the population of the study
MDRD 1999	1628	United States	Renal clearance 125I-Iothalamate	SCr	39.8 ± 21.2	Characteristics of the study population:
						Male 60%
						Black patients 12%
						> 55 yr 42%
						Diabetic patients 6%
						Re-expressed in 2007 to be used with IDMS traceable creatinine assay (MDRD 175)
CKD EPI (PCr) 2009	8254	United States	Various (urinary clearance of exogenous markers)	SCr	68 ± 40	Characteristics of the study population:
						Male 57%
						Black patiens 32%
						> 65 yr 13%
						Diabetic patients 29%
Hoek 2003	123	The Nederlands	Renal clearance 125I-Iothalamate	CysC	Median = 81	Characteristics of the study population:
						Male 48%
						Median age 50 yr
						Diabetic patients 24%
CKDEPI (Cys C and mixed PCr + CysC) 2012	5352	United States	Various (urinary or plasma clearance of exogenous markers)	CysC alone and both CysC and SCr	68 ± 39	Characteristics of the study population:
						Male 58%
						Black patients 40%
						Age > 65 yr 13%
						Diabetic patients 32%
						Patients with BMI > 30 31%

Acronyms description can be found in the text. GFR: Glomerular filtration rate. CKD: Chronic kidney disease; CG: Cockcroft and Gault formula; BMI: Body mass index.