Apoptotic pathway induced by diallyl trisulfide in pancreatic cancer cells

Figure 3 Diallyl trisulfide modulates cell cycle progression in Capan-2 and H6C7 cells. Diallyl trisulfide (DATS) (100 μmol/L) arrested Capan-2 and H6C7 cells in G1/G0 phase and G2/S phase. The percentage of cells in different phases was determined in Capan-2 and H6C7 cells after treatment with 100 μmol/L DATS for 24 h. A: DATS (100 μmol/L) arrested more Capan-2 cells in G1/G0 phase (^aP < 0.05 vs H6C7 cells); B: No significant difference was found in the percentage of cells in the G2/S phase in both Capan-2 and H6C7 cells compared with control cells; C: DATS upregulated p21 and cyclin B1 expression and downregulated cyclin D1 expression in Capan-2 and H6C7 cells. Each data point is the mean of three independent experiments and expressed as mean ± SD.