An accurate predictor of liver failure and death after hepatectomy: A single institution’s experience with 478 consecutive cases

Table 3 Diagnostic characteristics of total bilirubin, international normalized ratio and combined criteria on postoperative day (3, 5, 7) in the prediction of liver failure-related death

Criteria	AUC	95%CI	Sensitivity	Specificity	P value	Cut-off value
POD 3
TBIL-r1	0.686	0.642-0.727	92.90%	51.70%	0.018	1.24
INR-r1	0.658	0.614-0.701	64.30%	64.90%	0.046	0.94
Combination1	0.719	0.676-0.759	64.30%	74.80%	0.005	0.0337
POD 5
TBIL-r1	0.918	0.890-0.941	85.70%	87.50%	1.0e-7	1.68
INR-r1	0.719	0.677-0.759	50.00%	94.80%	0.006	1.02
Combination1	0.951	0.927-0.968	92.90%	90.10%	9.0e-9	0.0379
TBIL	0.810	0.772-0.844	78.60%	81.50%	7.7e-5	51.0
INR	0.708	0.665-0.748	85.70%	64.40%	0.008	1.23
Combination2	0.829	0.792-0.861	99.80%	57.50%	2.8e-5	0.0164
POD 7
TBIL-r1	0.937	0.912-0.957	85.70%	91.60%	2.4e-8	1.61
INR-r1	0.796	0.757-0.831	71.40%	80.00%	1.5e-4	0.91
Combination1	0.975	0.956-0.987	92.90%	94.40%	1.4e-9	0.0566
TBIL	0.886	0.854-0.913	92.90%	79.10%	1.0e-6	49.5
INR	0.798	0.760-0.833	85.70%	73.30%	1.4e-4	1.22
Combination2	0.908	0.879-0.933	92.90%	79.70%	8.7e-7	0.0277

¹The combination of TBIL-r1 and INR-r1 used the predicted probabilities, which were calculated using logistic regression analysis;

²The combination of TBIL and INR used the predicted probabilities, which were calculated using logistic regression analysis. AUC: Area under the receiver operating curve; TBIL: Total bilirubin; INR: International normalized ratio; TBIL-r1: The ratio of total bilirubin on postoperative day (POD) X to the value on POD 1; INR-r1: The ratio of international normalized ratio on POD X to the value on POD 1.