Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome

Table 3 The relation of expression of hMSH2, hMLH1, TβRII, E-cadherin, β-catenin, matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-2 with clinicopathological characteristics of Lynch syndrome and sporadic colorectal carcinoma

Clinicopathological parameter	n	hMSH2	hMLH1	TGFβRII	E-cadherin	Cytomembraneβ-catenin	Cytoplasmicβ-catenin	MMP-7	TIMP-2
Lynch syndrome	30	7	16	12	26	25	14	14	19
Male	23	4	10	10	21	20	9	12	14
Female	7	3	6	2	5	5	5	2	5
Tumor size
< 4 cm	16	4	8	7	14	13	8	8	10
≥ 4 cm	14	3	8	5	12	12	6	6	9
Position
Right half of colon	18	4	9	7	16	16	9	10	11
Left half of colon	3	1	2	1	3	2	1	1	2
Rectum	9	1	5	4	7	7	4	3	6
Invasion
Inner chorion	21	5	10	11a	21a	20a	7	7	17ac
Outer chorion	9	2	6	1	5	5	7a	7a	2c
Metastasis
No	21	4	11	11a	21a	20a	7	6	18ac
Yes	9	3	5	1	5	5	7a	8a	1
Sporadic CRC	30	19	25	22	18	15	24	26	6
Male	20	12c	17c	14	11	10	17	18	4
Female	10	7	8	8	7	5	7	8	2
Tumor size
< 4 cm	13	9c	11c	9	8	7	11	10	4
≥ 4 cm	17	10c	14	13	10	8	13	16	2
Position
Right half of colon	14	8c	11	12	9	9	12	13	3
Left half of colon	5	4	4	3	3	2	3	4	1
Rectum	11	7c	10	7	6	4	9	9	2
Invasion
Inner chorion	14	7	11	13ac	12a	10a	9	10c	5a
Outer chorion	16	12c	14	9b	6	5	15a	16a	1
Metastasis
No	12	7c	10	12ac	10a	9a	7	8c	5a
Yes	18	12	15	10c	8	6	17a	18a	1

^aCompared within the group;

^cCompared between groups, P < 0.05. CRC: Colorectal carcinoma; TGFβRII: Transforming growth factor-β type II receptor; MMP-7: Matrix metalloproteinase-7.