Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome

Table 2 The expression of hMSH2, hMLH1, TGFβRII, E-cadherin, β-catenin, matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-2 in three groups

Group	n	hMSH2			hMLH1			TGFβRII			E-cadherin		Cytomembraneβ-catenin		Cytoplasmicβ-catenin		MMP-7			TIMP-2
		-	+	++	-	+	++	-	+	++	-	+	-	+	-	+	-	+	++	-	+	++
Lynch syndrome	30	23a	7	0	14a	9	7	18a	8	4	4	26a	5	25a	16a	14	16a	11	3	11	15a	4
Sporadic CRC	30	11c	19	0	5c	11	14	8c	14	8	12c	18	15c	15	6	24c	4	16	10c	24	6	0
Adjacent tissues	8	0	1	7e	0	0	8e	0	1	7e	0	8	0	8	8e	0	8e	0	0	8e	0	0

^aLynch syndrome vs sporadic CRC;

^cSporadic CRC vs adjacent tissues;

^eLynch syndrome vs adjacent tissues, P < 0.05. CRC: Colorectal carcinoma.