Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions

Table 4 Genotype-specific ulcerative colitis odds ratios (with 95%CI) for combinations of variants in IL23R and IBD5

	SLC22A4		SLC22A5		IGR2230a_1		IGR2198a_1		IGR2096a_1
	CC	CT + TT	GG	GC + CC	GG	AG + AA	GG	GC + CC	GG	GT + TT
IL23R rs1004819
GG	1	1.298	1	1.064	1	0.941	1	1.033	1	1.104
		(0.782-2.156)		(0.623-1.815)		(0.556-1.593)		(0.623-1.711)		(0.666-1.831)
		P = 0.313		P = 0.821		P = 0.822		P = 0.900		P = 0.702
GA + AA	1.527	12.015	1.424	11.691	1.300	1.549	1.263	11.803	1.281	11.911
	(0.872-2.673)	(1.230-3.300)	(0.776-2.614)	(1.003-2.821)	(0.716-2.359)	(0.927-2.588)	(0.736-2.166)	(1.096-2.966)	(0.744-2.206)	(1.162-3.143)
	P = 0.138	P = 0.005	P = 0.253	P = 0.048	P = 0.388	P = 0.093	P = 0.396	P = 0.020	P = 0.372	P = 0.010
IL23R rs2201841
TT+TC	1	1.328	1	1.254	1	1.184	1	1.296	1	1.385
		(0.989-1.927)		(0.868-1.812		(0.823-1.704)		(0.922-1.822)		(0.982-1.953)
		P = 0.058		P = 0.228		P = 0.363		P = 0.136		P = 0.063
CC	13.413	1.716	13.946	1.474	13.777	1.411	13.165	1.592	12.977	11.701
	(1.169-9.965)	(0.788-3.739	(1.232-12.645)	(0.679-3.200)	(1.181-12.084)	(0.652-3.056)	(1.088-9.206)	(0.735-3.449)	(1.099-8.066)	(0.765-3.784)
	P = 0.018	P = 0.171	P = 0.014	P = 0.324	P = 0.018	P = 0.381	P = 0.027	P = 0.236	P = 0.026	P = 0.189

¹Associations significant at P < 0.05 vs controls.