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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 7, 2014; 20(1): 219-227
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.219
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.219
Table 2 Case-control genotypes and allele frequencies of variants in IL23R and inflammatory bowel disease-5 locus n (%)
UC (n = 320) | Controls (n = 316) | OR (95%CI)1 | P value | |
IL23R (rs1004819) | ||||
GG | 126 (39.4) | 158 (50.0) | ||
GA | 168 (52.5) | 134 (42.4) | ||
GA + AA | 194 (60.6) | 158 (50.0) | 1.606 (1.160-2.223)a | 0.004a |
AA | 26 (8.1) | 24 (7.6) | 1.254 (0.696-2.261) | 0.452 |
RAF | 0.343 | 0.287 | 0.032a | |
IL23R (rs2201841) | ||||
TT | 140 (43.8) | 155 (49.1) | ||
TC | 150 (46.9) | 143 (45.3) | ||
TC + CC | 180 (56.3) | 161 (51.0) | 1.268 (0.920-1.749) | 0.147 |
CC | 30 (9.4) | 18 (5.7) | 1.983 (1.069-3.678)a | 0.030a |
RAF | 0.328 | 0.283 | 0.242 | |
SLC22A4 (rs1050152) | ||||
CC | 93 (29.1) | 110 (34.8) | ||
CT | 159 (49.7) | 148 (46.8) | ||
CT + TT | 227 (71.0) | 206 (65.2) | 1.319 (0.935-1.86) | 0.115 |
TT | 68 (21.3) | 58 (18.4) | 1.150 (0.768-1.723) | 0.498 |
RAF | 0.46 | 0.417 | 0.120 | |
SLC22A5 (rs2631367) | ||||
GG | 83 (25.9) | 89 (28.2) | ||
GC | 163 (50.9) | 156 (49.4) | ||
GC + CC | 237 (74.0) | 227 (71.9) | 1.138 (0.794-1.631) | 0.481 |
CC | 74 (23.1) | 71 (22.5) | 0.982 (0.669-1.440) | 0.925 |
RAF | 0.485 | 0.471 | 0.607 | |
IGR2230a_1 (rs17622208) | ||||
GG | 87 (27.2) | 90 (28.5) | ||
AG | 160 (50.0) | 157 (49.7) | ||
AG + AA | 233 (72.8) | 226 (71.5) | 1.073 (0.751-1.532) | 0.698 |
AA | 73 (22.8) | 69 (21.8) | 0.990 (0.673-1.457) | 0.960 |
RAF | 0.478 | 0.466 | 0.685 | |
IGR2198a_1 (rs11739135) | ||||
GG | 105 (32.8) | 117 (37.0) | ||
GC | 159 (49.7) | 150 (47.5) | ||
GC + CC | 215 (67.2) | 199 (63.0) | 1.260 (0.900-1.763) | 0.179 |
CC | 56 (17.5) | 49 (15.5) | 1.169 (0.760-1.797) | 0.477 |
RAF | 0.423 | 0.392 | 0.260 | |
IGR2096a_1 (rs12521868) | ||||
GG | 101 (31.6) | 117 (37.0) | ||
GT | 164 (51.3) | 147 (46.5) | ||
GT + TT | 219 (68.5) | 199 (63.0) | 1.256 (0.897-1.760) | 0.185 |
TT | 55 (17.2) | 52 (16.5) | 1.045 (0.680-1.608) | 0.840 |
RAF | 0.428 | 0.397 | 0.262 |
- Citation: Sarlos P, Varszegi D, Csongei V, Magyari L, Jaromi L, Nagy L, Melegh B. Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions. World J Gastroenterol 2014; 20(1): 219-227
- URL: https://www.wjgnet.com/1007-9327/full/v20/i1/219.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i1.219