Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions

Table 2 Case-control genotypes and allele frequencies of variants in IL23R and inflammatory bowel disease-5 locus n (%)

	UC (n = 320)	Controls (n = 316)	OR (95%CI)1	P value
IL23R (rs1004819)
GG	126 (39.4)	158 (50.0)
GA	168 (52.5)	134 (42.4)
GA + AA	194 (60.6)	158 (50.0)	1.606 (1.160-2.223)a	0.004a
AA	26 (8.1)	24 (7.6)	1.254 (0.696-2.261)	0.452
RAF	0.343	0.287		0.032a
IL23R (rs2201841)
TT	140 (43.8)	155 (49.1)
TC	150 (46.9)	143 (45.3)
TC + CC	180 (56.3)	161 (51.0)	1.268 (0.920-1.749)	0.147
CC	30 (9.4)	18 (5.7)	1.983 (1.069-3.678)a	0.030a
RAF	0.328	0.283		0.242
SLC22A4 (rs1050152)
CC	93 (29.1)	110 (34.8)
CT	159 (49.7)	148 (46.8)
CT + TT	227 (71.0)	206 (65.2)	1.319 (0.935-1.86)	0.115
TT	68 (21.3)	58 (18.4)	1.150 (0.768-1.723)	0.498
RAF	0.46	0.417		0.120
SLC22A5 (rs2631367)
GG	83 (25.9)	89 (28.2)
GC	163 (50.9)	156 (49.4)
GC + CC	237 (74.0)	227 (71.9)	1.138 (0.794-1.631)	0.481
CC	74 (23.1)	71 (22.5)	0.982 (0.669-1.440)	0.925
RAF	0.485	0.471		0.607
IGR2230a_1 (rs17622208)
GG	87 (27.2)	90 (28.5)
AG	160 (50.0)	157 (49.7)
AG + AA	233 (72.8)	226 (71.5)	1.073 (0.751-1.532)	0.698
AA	73 (22.8)	69 (21.8)	0.990 (0.673-1.457)	0.960
RAF	0.478	0.466		0.685
IGR2198a_1 (rs11739135)
GG	105 (32.8)	117 (37.0)
GC	159 (49.7)	150 (47.5)
GC + CC	215 (67.2)	199 (63.0)	1.260 (0.900-1.763)	0.179
CC	56 (17.5)	49 (15.5)	1.169 (0.760-1.797)	0.477
RAF	0.423	0.392		0.260
IGR2096a_1 (rs12521868)
GG	101 (31.6)	117 (37.0)
GT	164 (51.3)	147 (46.5)
GT + TT	219 (68.5)	199 (63.0)	1.256 (0.897-1.760)	0.185
TT	55 (17.2)	52 (16.5)	1.045 (0.680-1.608)	0.840
RAF	0.428	0.397		0.262

¹Adjusted for age and gender.

^aAssociations significant at P < 0.05 vs controls. RAF: Risk allele frequency; UC: Ulcerative colitis.