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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 7, 2014; 20(1): 204-213
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.204
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.204
Table 2 Conditional maximum likelihood estimation of the associations between UNC5C variants and risk for colorectal cancer n (%)
Type of cancer | Patients mut/total | Controls mut/total | OR (95%CI) | P value |
Variant A628K1 | ||||
Familial CRCs without MMR mutations | 0/120 (0.00) | 2/1121 (0.18) | NA | NA |
Familial CRCs or Lynch-associated cancers without MMR mutations | 1/178 (0.56) | 2/1121 (0.18) | 3.2 (0.29-35.05) | 0.348 |
Familial CRCs or Lynch-associated cancers with or without MMR mutations | 3/310 (0.97) | 2/1121 (0.18) | 5.5 (0.91-32.87) | 0.063 |
Sporadic CRCs (ASTERISK) | 4/1023 (0.39) | 2/1121 (0.18) | 2.2 (0.40-12.02) | 0.364 |
Familial and sporadic CRCs | 7/1333 (0.53) | 2/1121 (0.18) | 3.0 (0.61-14.25) | 0.177 |
Variants R603C, T617I, A628K, or Q630E2 | ||||
Familial CRCs without MMR mutations | 2/120 (1.67) | 37/4300 (0.86) | 2.0 (0.47-8.20) | 0.3613 |
Familial CRCs or Lynch-associated cancers without MMR mutations | 3/178 (1.69) | 37/4300 (0.86) | 2.0 (0.60-6.47) | 0.2613 |
Familial CRCs or Lynch-associated cancers with or without MMR mutations | 5/310 (1.61) | 37/4300 (0.86) | 1.9 (0.74-4.84) | 0.1853 |
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Citation: Küry S, Garrec C, Airaud F, Breheret F, Guibert V, Frenard C, Jiao S, Bonneau D, Berthet P, Bossard C, Ingster O, Cauchin E, Bezieau S. Evaluation of the colorectal cancer risk conferred by rare
UNC5C alleles. World J Gastroenterol 2014; 20(1): 204-213 - URL: https://www.wjgnet.com/1007-9327/full/v20/i1/204.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i1.204