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©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 7, 2014; 20(1): 204-213
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.204
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.204
Table 1 Patients with familial colorectal or Lynch-associated cancers included in the study
Patients with CRC (fulfilling Amsterdam II and/or Bethesda criteria) | Patients with family history of CRC and personal history of colorectal polyposis or of cancer in the Lynch syndrome tumor spectrum | Patients with Lynch syndrome (with identified MMR mutation or variant of unknown significance) | |
Total number of patients | 120 | 581 | 132 |
MSI | 50 | 13 | 132 |
MSS | 37 | 16 | 0 |
Unknown | 33 | 29 | 0 |
Revised Bethesda criteria | 97 | 17 | 132 |
MSI | 38 | 4 | 132 |
MSS | 31 | 3 | 0 |
Unknown | 28 | 10 | 0 |
Amsterdam II criteria | 41 | 15 | ND |
MSI | 14 | 4 | |
MSS | 14 | 3 | |
Unknown | 13 | 8 | |
First-degree relatives with CRC | 23 | 13 | ND |
MSI | 12 | 3 | |
MSS | 6 | 3 | |
Unknown | 5 | 7 | |
Polyps (> 10 polyps) | 0 | 0 | 0 |
Polyps ( ≤ 10 polyps) at age < 50 +/- first-degree relatives with polyps, MUTYH-negative | 0 | 41 | ND |
MSI | 9 | ||
MSS | 13 | ||
Unknown | 19 |
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Citation: Küry S, Garrec C, Airaud F, Breheret F, Guibert V, Frenard C, Jiao S, Bonneau D, Berthet P, Bossard C, Ingster O, Cauchin E, Bezieau S. Evaluation of the colorectal cancer risk conferred by rare
UNC5C alleles. World J Gastroenterol 2014; 20(1): 204-213 - URL: https://www.wjgnet.com/1007-9327/full/v20/i1/204.htm
- DOI: https://dx.doi.org/10.3748/wjg.v20.i1.204