Abstracts Open Access
Copyright ©The Author(s) 1996. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 15, 1996; 2(Suppl1): 158-158
Published online Sep 15, 1996. doi: 10.3748/wjg.v2.iSuppl1.158
Effect of ranitidine plus cisapride and ranitidine with gastroesophageal reflux disease
Li Yang, Chao-Ying Li, Jun-Chao Wu, Yi-Ping Wang, Wei Wang, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, Sichuan Province, China
Author contributions: All authors contributed equally to the work.
Received: August 11, 1995
Revised: March 21, 1996
Accepted: June 15, 1996
Published online: September 15, 1996

Abstract

AIM: To investigate the effect of ranitidine and cisapride in gastroesophageal reflux disease (GERD) therapy.

METHODS: 42 patients, who having reflux symptom, 24-h esophagitis confirmed by endoscopy were randomized to two groups. One group was treated by ranitidine (300 mg, bid) plus cisapride (5 mg, tid) (R + C group, n = 25), another by ranitidine (300 mg, bid) (R group, n = 24) for 4 wk.

RESULTS: (1) The symptom relief rate was 88.00% in R + C group, 58.33% in R group (P < 0.05); (2) The effective rate of esophageal pH monitoring was 84.62%, 50.00% (P > 0.05).

CONCLUSION: The results indicate ranitidine plus cisapride is more effective than ranitidine for the treatment of GERD.

Key Words: Ranitidine, Cisapride, Gastroesophageal reflux disease



Footnotes

Original title: China National Journal of New Gastroenterology (1995-1997) renamed World Journal of Gastroenterology (1998-).

E- Editor: Liu WX

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