Effect of thienorphine on intestinal transit and isolated guinea-pig ileum contraction

Figure 5 Effects of thienorphine, buprenorphine and morphine on the basal tonus of spontaneous movement of the guinea-pig ileum. Each point represents the mean ± SE (n = 5 or 6 preparations). A: Thienorphine (Thie) or buprenorphine (Bup) concentration-dependently decreased the basal tonus of guinea-pig ileum (GPI); B: Morphine (Mor) concentration-dependently increased the basal tonus of GPI; C: Naloxone (NLX, 0.50 mmol/L), Thie (32.0 μmol/L) or Bup (32.0 μmol/L) antagonized the elevation of basal tonus of GPI induced by Mor (2.4 mmol/L). ^aP < 0.05, ^bP < 0.001 vs the basal tonus before chemical application.