Endoscopic and surgical resection of T1a/T1b esophageal neoplasms: A systematic review

Table 1 Forty-two studies were included in the analysis of endoscopically resected patients

Author	EMR/ESD	Patients	Surgery	ADC/SCC	Positive resection margin	Other therapy	Local recurrence	Meta-chronous	N (+)	L (+)	Re-classification	Grade 3	In situ	Piecemeal resection
Buttar et al[10]	EMR	17	0	ADC	3	PDT					8		0
Chaves et al[11]	ESD	5		SCC	0		0						3	1
Chennat et al[12]	EMR	49	3	ADC			0				22		0
Ciocirlan et al[13]	EMR	51	2	SCC	14	CHEMO	8	2				0	4	36
Conio et al[14]	EMR	39	3	ADC			0	1		2	10	5	0
Ell et al[15]	EMR	64	5	ADC		PDT/APC	6	3			6	6	0
Espinel et al[16]	EMR	4	1	ADC							1	0	0
Fujishiro et al[17]	ESD	43		SCC	7		1	1		1			24	0
Gerke et al[18]	EMR	41		ADC	9	RFA	3	0					0
Goda et al[19]	EMR	58	1	SCC		CRT				1			0
Higuchi et al[20]	EMR	20	0	SCC	6	CRT/APC	0	0	0	6		1	0
Hull et al[52]	EMR	10		ADC							2		0
Iguchi et al[21]	EMR	8	1	SCC								0	4
Ishihara et al[22]	EMR/ESD	70		SCC		CRT	12			0			40
Ishii et al[23]	ESD	35	1	SCC	2	CHEMO	0			1			28	0
Larghi et al[24]	EMR	40	5	ADC		PDT/APC	0				6		19
Lewis et al[25]	EMR	100	1	ADC	1	PDT			1		8
Lin et al[26]	EMR	9	1	SCC	0		1		0	0	1	0	7
Lopes et al[27]	EMR	41	1	ADC		APC/CRT	4	2			14		2
Maish et al[28]	EMR	7	7	ADC	1				0		4		0
Manner et al[6]	EMR/ESD	21	1	ADC	27	APC	3	2		0		0	0
Naritaka et al[29]	EMR	13	1	SCC	2	RT	1						7	9
Nijhawan et al[30]	EMR	25	2	ADC		PDT	0				11
Noguchi et al[31]	EMR	33	5	SCC		CRT			0	5	14		15
Nomura et al[32]	EMR	51	1	SCC		CRT	4						30	41
Nonaka et al[33]	ESD	25	1	SCC	3	RT/CRT	0				10		0	0
Ohashi et al[90]	EMR	179		SCC						13			68
Ono et al[34]	ESD	84	9	SCC	7	CRT	1	2	2				0	0
Ota et al[35]	EMR	18	0	SCC	5	CRT	0		4	11		3	0
Pech et al[3]	EMR/ESD	39		SCC	20	PDT/CHEMO	5		2	7		1	10
Peters et al[53]	EMR/ESD	141		ADC	37					1	73	14
Pouw et al[37]	EMR/ESD	34	1	ADC		APC	3				14		10
Prasad et al[39]	EMR	25	25	ADC	17				5		16
Repici et al[51]	ESD	20	2	SCC	1		0	0	1			2	3	0
Scheil-Bertram et al[40]	EMR	16	16	ADC					16				1
Schröder et al[41]	EMR	16		ADC/SCC	9				3	13		1
Shimizu et al[42]	EMR	82		SCC		APC	2	12					16
Takeo et al[44]	EMR	29	5				0		0		15		10
Tanabe et al[46]	EMR	85	0	SCC	15	APC/CRT	5						0	41
Teoh et al[47]	EMR/ESD	28		SCC	6	RT/CRT	1			1
Urabe et al[48]	EMR/ESD	122		SCC			6						56
Vieth et al[54]	EMR	295		ADC	210					10		22
Yokoyama et al[49]	EMR	17	0	SCC		RT							7
Zehetner et al[50]	EMR	28	3	ADC	0	RFA	5	3		2		2

EMR: Endoscopic mucosal resection; ESD: Endoscopic submucosal dissection; SCC: Squamous carcinoma; ADC: Adenocarcinoma; APC: Argon plasma coagulation; PDT: Photodynamic therapy; CRT: Chemoradiation therapy; RFA: Radiofrequency ablation; RT: Radiology; CHEMO: Chemotherapy.