Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression

Figure 3 Expression of KCNE2 and estrogen receptor in adenocarcinoma area. A: Low power magnification of a transitional area from the non-neoplastic mucosal layer with intramucosal cystic lesions (left) to the intramucosal adenocarcinoma (right, HE, × 40); B: High power magnification (A, squared area) around the intramucosal adenocarcinoma (circled by white-hatched line, HE, × 200); C: KCNE2 immunostaining of a serial section of (B) shows that KCNE2 expression is almost negative in adenocarcinoma (circled by black-hatched line), while the surrounding non-neoplastic glands are positive (× 200); D: Estrogen receptor immunostaining of serial sections of (B) and (C) show that estrogen receptor is equally expressed in both cancerous (circled by black-hatched line) and non-neoplastic glands (× 200).