Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression

Figure 2 Expression of KCNE2 and estrogen receptor in non-neoplastic cystic lesion by immunohistochemistry. A: Low power magnification of a transitional area from the non-neoplastic mucosal layer with intramucosal cystic lesions (left) to the intramucosal adenocarcinoma (right, HE, × 40); B: High power magnification (A, squared area) around the intramucosal cystic lesion (asterisk, HE, × 200); C: KCNE2 immunostaining of a serial section of (B) shows that KCNE2 is almost negative in the dilated cystic gland (asterisk), while the surrounding non-cystic glands are positive (× 200); D: Estrogen receptor immunostaining of serial sections of (B) and (C) show that ER is equally expressed in both cystic (asterisk) and non-cystic glands (× 200).