Inhibition of pacemaker activity in interstitial cells of Cajal by LPS via NF-κB and MAP kinase

Figure 6 Effects of mitogen-activated protein kinases inhibitors on prostaglandin E2-induced action in interstitial cells of Cajal. A: Pacemaker currents of interstitial cells of Cajal (ICCs) treated with 5 μmol/L prostaglandin E2 (PGE₂) at a holding potential of -70 mV; B: Pacemaker currents after pretreatment with PD 98059 (10 μmol/L) prior to PGE₂ treatment; C: Pacemaker currents after pretreatment with SB 203580 (10 μmol/L) prior to PGE₂ treatment. The effects of mitogen-activated protein kinases inhibitors on the PGE₂-induced action are summarized in D and E. Bars represent mean ± SE values (n = 4 per group). ^aP < 0.05 vs PGE₂. Con: Control, PD: PD 98059, SB: SB203580.